Testing the auditory steady-state response (ASSR) to 40-Hz and 27-Hz click trains in children with autism spectrum disorder and their first-degree biological relatives: A high-density electroencephalographic (EEG) study.

ABSTRACT:

Motivation

Altered auditory processing likely contributes to core social and attentional impairments in autism spectrum disorder (ASD). The auditory steady-state response (ASSR)- a neural measure of auditory processing and cortical excitatory-inhibitory balance-has yielded mixed results in ASD. This study uses high density electroencephalography (EEG) to evaluate ASSR in ASD and unaffected siblings to clarify neural mechanisms underlying auditory deficits in autism.

Methods

High-density 70-channel EEG was recorded in children (8-12 years, IQ >80) with ASD (n=53), typically developing (TD) peers (n=35), and unaffected biological siblings (n=26) during 500-ms binaural click trains (27- and 40-Hz) in an active oddball task.

Results

No group differences were observed in f

SUBMITTER: Darrell M 

PROVIDER: S-EPMC12340784 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature