Three-dimensional ultrastructural differences between thalamic and non-thalamic recipient layers in macaque V1.

ABSTRACT: Understanding the synaptic characteristics of each cortical layer is essential for elucidating the functional architecture of each brain region. In the current study, we made a detailed quantitative comparison of the synaptic structure in the predominantly input layers of primate primary visual cortex (layer 4C) and in the predominant output layer (layer 3B) using focused ion beam scanning electron microscopy (FIB/SEM). We quantified the synaptic density in each layer, classified synaptic boutons according to their number of synapses and mitochondrial content, and quantified key morphometric parameters, including bouton volume, postsynaptic density (PSD) area and morphology, volume occupied by mitochondria, and postsynaptic targets. Our results revealed that for all the layers there is a h

SUBMITTER: Garcia-Marin V 

PROVIDER: S-EPMC12340792 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature