Autophagy functions in lung macrophages and dendritic cells to regulate allergen-dependent inflammatory responses.

ABSTRACT: Asthma affects 260 million people worldwide, with severe asthma cases that are associated with T_H17/T_H1 responses and neutrophil dominated inflammation being the most difficult to treat due to corticosteroid insensitivity. Single nucleotide polymorphisms in the ATG5 gene, which encodes for a protein required for the cellular recycling process of autophagy, are associated with higher risk for developing severe asthma. However, the role for ATG5 during allergic inflammation remains mostly unknown. We have identified an autophagy-dependent role for ATG5 in lung macrophages and dendritic cells (DCs) for suppressing T_H17 responses and neutrophil accumulation in house dust mite (HDM)-challenged mice, a T_H17/T_H1 dominated model for all

SUBMITTER: Dubey N 

PROVIDER: S-EPMC12340803 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature