Mapping of genotype-by-environment interaction loci for Metabolic Syndrome-like traits using the multi-parent <i>Drosophila</i> Synthetic Population Resource determines that main genetic effects are distinct from environment dependent plastic loci.

ABSTRACT: Metabolic Syndrome (MetS) risk, driven by genotype-environment interactions like diet, is rising globally. Due to its genetic and environmental complexity, the genetic architecture and interconnected traits underlying MetS is poorly understood. In Drosophila, genotype-by-diet interactions significantly influence MetS-like traits. This study used the Drosophila Synthetic Population Resource to dissect the genetic architecture of both genotypic and genotype-by-diet interaction effects underlying trait variation. The study hypotheses were: 1) Loci responsible for metabolic phenotypic variation should be shared across traits. 2) Genetic loci responsible for plasticity and epistatic interactions for metabolic traits should also be the loci responsible for the main effects. 3) Gene

SUBMITTER: Dew-Budd K 

PROVIDER: S-EPMC12340828 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature