Differential PaxillinB dynamics at <i>Dictyostelium</i> cell-substrate adhesions.

ABSTRACT: Adhesion-based migration is regulated by focal adhesions, multi-protein nanostructures linking the intracellular cytoskeleton to the extracellular substrate. Efficient adhesion-based migration has been shown to be regulated by focal adhesion dynamics such as lifetime, size and turnover, which in turn are influenced by the molecular composition of focal adhesions. We recently identified the formation of cell-substrate adhesion populations in Dictyostelium discoideum with differing molecular compositions, but it is unclear how these distinct compositions influence Dictyostelium adhesion dynamics and cell migration. Here, we further investigate the role of molecular composition on Dictyostelium adhesion lifetime and protein turnover during cell migration. We show that co-

SUBMITTER: Fierro Morales JC 

PROVIDER: S-EPMC12340833 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature