Zinc and Cobalt exposure influence <i>Akkermansia muciniphila</i> growth and short-chain fatty acid metabolism.

ABSTRACT: Akkermansia muciniphila is a probiotic bacterium that has been proposed as a potential intervention for depression. A. muciniphila is a common mucin degrader, producing short fatty chain acids (SCFAs), including acetate, butyrate, and propionate, which can help regulate mood via the gut-brain axis. However, the interplay between A. muciniphila and other neuroactive environmental exposures is unclear. The objective of this study was to assess the effects of Zn and Co exposure, individually and together, on A. muciniphila growth and SCFA production. Minimum Inhibitory Concentration (MIC) was calculated for each metal, and sub-MIC exposure testing at high and low levels was conducted with single and combined metals. Growth curves were measured for each exposure con

SUBMITTER: Eggers S 

PROVIDER: S-EPMC12340866 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature