Vancomycin Sensitization in <i>Pseudomonas aeruginosa</i> is Contingent on Limited Metabolic Flux.

ABSTRACT: The global antibiotic resistance crisis causes nearly 5 million deaths annually. Pseudomonas aeruginosa, a virulent Gram-negative bacterium, is a major cause of hospital-acquired infections, often coexisting withStaphylococcus aureus. Previous studies showed P. aeruginosa can be sensitized to vancomycin through altered nutrient availability. This study explores the scope and mechanisms of this phenomenon using a dual-pronged approach focused on primary metabolism. Through the application of a tool compound that targets succinate dehydrogenase, we sought to correlate this sensitization to effects seen in minimal media growth. Carbon supplementation can partially restore tolerance with sources that aid in detecting environmental changes, low iron levels, and altered meta

SUBMITTER: Golden MM 

PROVIDER: S-EPMC12340952 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature