A Palladium-Catalyzed Cascade Double Annulation Strategy for Modular Access to Dihydrocyclopenta[<i>b</i>]chromenes.

ABSTRACT: The cyclopentachromene skeleton is a key structural motif in pharmaceutical and fluorescent materials. We here introduce a Pd-promoted double ring-closure strategy for tackling the modular synthesis of densely functionalized dihydrocyclopenta[b]chromenes, which proceeds simply from two reaction partners with high diversity. This scheme features a reaction sequence beginning with 1,6-conjugate addition of ortho-alkynyl quinone methide, followed by annulation and migratory insertion. This approach is compatible with functional groups, providing a streamlined pathway to access complex five-membered ring-fused chromenes.

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12340954 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature