Antimicrobial Peptides Can Facilitate Whole Blood Safety from Bacteria: A Proof of Concept.

ABSTRACT: With continuous improvements to blood donor deferrals and the availability of sensitive tests for donation screening for infectious agents, bacterial contamination of whole blood (WB) and blood components stored for transfusion is a rare event. Nonetheless, it still occurs and remains a transfusion-associated risk in terms of septic transfusion reactions (STRs) and transfusion-transmitted bacterial infections with morbidity and mortality outcomes. One of the risk mitigation strategies for bacterial contamination is to implement treatment with currently available proactive pathogen reduction technologies (PRTs) for these transfusion products. Here, as a proof of concept, we tested two recently developed unique cationic antimicrobial peptides (AMPs; D-CONGA and D-CONGA-Q7) for WB safety from

SUBMITTER: Chattagul S 

PROVIDER: S-EPMC12340958 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature