Sialic Acid-Containing Glycolipids Extend the Receptor Repertoire of Enterovirus-D68.

ABSTRACT: Enterovirus D68 (EV-D68) emerged as a pathogen of increasing health concern globally, particularly due to its association with outbreaks of severe respiratory diseases and acute flaccid myelitis (AFM) in children. Knowledge regarding the tissue tropism and pathogenesis of EV-D68 within the respiratory tract and central nervous system remains limited, primarily due to an incomplete understanding of the host factors that facilitate the entry of EV-D68 into host cells. Several cellular receptors involved in EV-D68 infections have been identified, including ICAM-5, sialylated glycoproteins, and heparan sulfate (HS). Here, we investigate the receptor requirement of a panel of EV-D68 strains covering all clades, focusing on HS and sialosides utilizing glycan arrays. We found that all EV-D68 stra

SUBMITTER: Pereirinha da Silva AK 

PROVIDER: S-EPMC12340969 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature