Extracellular vesicles from Distinct <i>Histoplasma capsulatum</i> Strains Modulate Phagocyte Function and Promote Fungal Persistence.

ABSTRACT: Fungal extracellular vesicles (EVs) are lipid-bilayer compartments that transport a wide range of molecules, including proteins, polysaccharides, pigments, small metabolites, lipids, and RNA. In fungal pathogens, EVs harbor virulence factors as well as antigenic determinants that modulate the host immune response. In this work, we investigated the modulatory effects of EVs released by two phenotypically and genotypically distinct strains of Histoplasma capsulatum (G-217B and G-184A) on bone marrow-derived macrophages (BMDMs) and bone marrow-derived dendritic cells (BMDCs). Both host cells internalized H. capsulatum EVs, which appeared to elicit distinct functional responses. Treatment of BMDMs with EVs from either strain (EV_HcG-184A and EV_HcG-217B) incre

SUBMITTER: Souza TN 

PROVIDER: S-EPMC12340971 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature