Evaluation of the safety profile of a metal-based nanosystem for developing antimicrobial polymer membranes in healthcare applications.

ABSTRACT: Healthcare-associated infections remain a significant concern, driving the exploration of metal-based nanosystems as innovative solutions for developing antimicrobial polymer membranes. This study evaluates the toxicity of a novel nanofiber membrane reinforced with multimetallic silica nanohybrids, proposed as an advanced antimicrobial layer. Initially, silver (Ag), copper (Cu), and cobalt (Co) were doped into silica nanoparticles (SiNPs) via the sol-gel method. The trimetallic nanohybrid demonstrated superior antimicrobial activity compared to Ag-, Cu-, or Co-doped SiNPs alone, showing enhanced efficacy against Gram-positive and Gram-negative bacteria, as well as fungi, due to the synergistic action of the metals. Toxicity was assessed using zebrafish embryo assays (OECD 236) with

SUBMITTER: Yapa P 

PROVIDER: S-EPMC12340984 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature