Genetic overlap between functional impairment and depression and anxiety symptom severity: evidence from the GLAD Study.

ABSTRACT:

Background

Functional impairment in daily activities, such as work and socializing, is part of the diagnostic criteria for major depressive disorder and most anxiety disorders. Despite evidence that symptom severity and functional impairment are partially distinct, functional impairment is often overlooked. To assess whether functional impairment captures diagnostically relevant genetic liability beyond that of symptoms, we aimed to estimate the heritability of, and genetic correlations between, key measures of current depression symptoms, anxiety symptoms, and functional impairment.

Methods

In 17,130 individuals with lifetime depression or anxiety from the Genetic Links to Anxiety and Depression (GLAD) Study, we analyzed total scores from the Patient Health Questionnaire-9

SUBMITTER: Skelton M 

PROVIDER: S-EPMC12341029 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature