Differences and similarities between the genetic architecture of lifetime substance use across different substances.

ABSTRACT:

Background

Illicit drug use may lead to dependence on those drugs, is associated with various psychiatric disorders, and can have hazardous, sometimes life-threatening, consequences. We investigated the genetic architecture underlying the lifetime use (LU) of several drugs, individually and in combination.

Methods

We conducted genome-wide association studies of LU of cocaine, methamphetamine, inhalants, illegal opioids, prescription opioids, and prescription stimulants in European (EUR), African (AFR), and Latin American (AMR)-ancestry subjects (cases ranging from n = 4,900-21,850 [EUR], n = 519-9,802 [AFR], and n = 899-5,012 [AMR]; controls from n = 93,763-110,658 [EUR], n = 37,261-46,509 [AFR], and n = 31,412-35,501 [AMR]). We also

SUBMITTER: Bright U 

PROVIDER: S-EPMC12341034 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature