Associations of serotonin-related brain morphology in early adolescence with behavioral and emotional problems.

ABSTRACT: We aimed to investigate the association of brain morphology with behavioral and emotional problems in early adolescence using a brain atlas of the serotonin system. This pre-registered study used data from the Generation R Study, a large birth cohort in Rotterdam, the Netherlands. A total of 2492 children were included at age 10 years, with neuroimaging data and self-reported behavioral and emotional problems. Cortical surface area and thickness were measured in ten serotonin-coupled brain regions. Our primary analysis revealed that higher total, attention, and externalizing problem scores were associated with smaller cortical surface area in Regions 8, 9, and 10 (covering cingulate, orbitofrontal, temporal, and parietal areas) after adjusting for intracranial volume, highlighting region-s

SUBMITTER: Koc D 

PROVIDER: S-EPMC12341630 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature