Effects of exercise on inflammation, circulating tumor cells, and circulating tumor DNA in colorectal cancer.

ABSTRACT:

Background

The biological mechanisms by which postdiagnosis physical activity improves disease-free survival in colorectal cancer survivors remain incompletely understood. This trial tested the hypothesis that 12 weeks of moderate-intensity aerobic exercise, when compared with a control group, would change inflammation, circulating tumor cells (CTCs), and circulating tumor DNA (ctDNA) in a manner consistent with an improved cancer prognosis.

Methods

This trial randomized Stages I-III colorectal cancer survivors to 12 weeks of home-based moderate-intensity aerobic exercise or a waitlist control group. The co-primary endpoints were high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6), secondary endpoints were soluble tumor necrosis factor-α receptor 2 (sTNFαR2

SUBMITTER: Brown JC 

PROVIDER: S-EPMC12341639 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature