Quantified motility in Crohn's disease to evaluate stricture composition using cine-MRI.

ABSTRACT:

Objectives

The histopathological composition of a stricture impacts clinical treatment choice. Therefore, imaging biomarkers that can distinguish a predominantly inflammatory from a chronic (i.e., non-inflammatory) stricture are highly relevant. The aim of our study was to determine whether it is possible to distinguish inflammatory (i.e., inflammatory and mixed) from chronic (i.e., non-inflammatory) strictures using quantified motility measured on cine-MRI in Crohn's disease (CD) patients.

Methods

In this prospective cross-sectional study, consecutive CD patients scheduled for small bowel resection underwent 2D cine-MRI prior to surgery. The motility of small bowel strictures and pre-stricture dilatations was quantified using a validated post-processing method (GIQuant). Th

SUBMITTER: Beek KJ 

PROVIDER: S-EPMC12341669 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature