Sex Differences in Associations of Lewy Body Disease with Alzheimer's Disease and Cognitive Decline.

ABSTRACT:

Objective

To investigate how sex and age at menopause influence the interplay between Alzheimer's disease (AD) and Lewy body disease (LBD) neuropathologies, and their associations with cognitive decline.

Methods

We analyzed data from: (1) three Rush Alzheimer's Disease Center cohorts (i.e., the Religious Orders Study, Rush Memory and Aging Project, and Minority Aging Research Study), and (2) the National Alzheimer's Coordinating Center Neuropathology Data Set. Neuropathological evaluation assessed LBD (neocortical/limbic-type vs none) and AD, including neuritic plaques (β-amyloid plaques surrounded by dystrophic neurites) and neurofibrillary tangles. In each dataset, we tested interactive associations between LBD and sex on neuritic plaques, neurofibrillary tangles, and cogn

SUBMITTER: Wood Alexander M 

PROVIDER: S-EPMC12341763 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature