Organ Specificity and Commonality of Epigenetic Aging in Low- and High-Running Capacity Rats.

ABSTRACT: Epigenetic drift, which is gradual age-related changes in DNA methylation patterns, plays a significant role in aging and age-related diseases. However, the relationship between exercise, epigenetics, and aging, and the molecular mechanisms underlying their interactions are poorly understood. Here, we investigated the relationship between cardiorespiratory fitness (CRF), epigenetic aging, and promoter methylation of individual genes across multiple organs in selectively bred low- and high-capacity runner (LCR and HCR) aged rats. Epigenetic clocks, trained on available rat blood-derived reduced representation bisulfite sequencing data, did not reflect differences in CRF between LCR and HCR rats across all four organs. However, we observed organ-specific differences in global mean DNA methyl

SUBMITTER: Kawamura T 

PROVIDER: S-EPMC12341768 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature