A Novel GH Deficient Rat Model Reveals Cross-Species Insights Into Aging.

ABSTRACT: Multiple studies in mice with genetically disrupted growth hormone (GH) signaling have demonstrated that such disruption results in reduced body size, robustly increased longevity (> 50% in some cases), and improvements across multiple health parameters. However, it remains unclear how generalizable these findings are across mammals. Evidence in rats is limited and inconsistent. These conflicting results highlight the need for further investigation into the role of GH signaling in longevity across species. To address this gap, we developed a novel GH-deficient rat model using CRISPR/Cas9 technology to introduce a 10 bp deletion in exon 3 of the gene encoding rat GH-releasing hormone (GHRH) yielding a non-functional GHRH product. Physiological characterization of GHRH knockout (KO) rats rev

SUBMITTER: Myint SMMP 

PROVIDER: S-EPMC12341780 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature