Cerebral Metabolic Rate of Oxygen and Accelerometry-Based Fatigability in Community-Dwelling Older Adults.

ABSTRACT: Alterations in energy metabolism may drive fatigue in older age, but prior research primarily focused on skeletal muscle energetics without assessing other systems and utilized self-reported measures of fatigue. We tested the association between energy metabolism in the brain and an objective measure of fatigability in the Study of Muscle, Mobility and Aging (N = 119, age 76.8 ± 4.0 years, 59.7% women). Total brain cerebral metabolic rate of oxygen (CMRO₂) was measured using arterial spin labeling and T₂-relaxation under spin tagging MRI protocols. Accelerometry-based fatigability status during a fast-paced 400 m walk was determined using the Pittsburgh Performance Fatigability Index (PPFI, higher = worse). Confounders included skeletal muscle energetics, measured in 

SUBMITTER: Gay EL 

PROVIDER: S-EPMC12341810 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature