Short-Term Severe Energy Restriction Promotes Molecular Health and Reverses Aging Signatures in Adults With Prediabetes in the PREVIEW Study.

ABSTRACT: Prediabetes, characterized by impaired fasting glucose and/or glucose tolerance, is associated with organ damage, increased mortality, and accelerated aging, even before diabetes onset. Severe short-term energy restriction while maintaining essential nutrient intake is among the most effective strategies for weight loss, metabolic health improvement, and delaying type 2 diabetes progression. Extracellular vesicles contribute to these metabolic benefits; however, the impact of energy-restriction-induced weight loss on the extracellular vesicle proteome remains incompletely understood. This study employed targeted and untargeted proteomics to investigate the effect of an 8-week severely energy-restricted diet on the plasma proteome in adults with prediabetes from Sydney, Australia, as part o

SUBMITTER: Cagigas ML 

PROVIDER: S-EPMC12341815 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature