Genomic evidence of spatially structured gene flow and divergent insecticide resistance backgrounds of the malaria vector Anopheles funestus in Tanzania.

ABSTRACT: Population genetic analysis of mosquitoes is important for understanding the distribution of insecticide resistance alleles, devising sustainable control approaches, and understanding how vector populations are structured in space. Anopheles funestus is the dominant malaria vector in most parts of East and Southern Africa. To better understand its population genetic structure in Tanzania, we sequenced the genomes of 334 individual An. funestus mosquitoes from 11 regions across the country. Signs of reduced migration between western and eastern cohorts across the semi-arid central region containing the Rift Valley suggest a partial barrier to gene flow between these populations. This was evidenced by population structure between the eastern and western cohorts, as well as asynchronous selec

SUBMITTER: Odero JO 

PROVIDER: S-EPMC12341887 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature