Hinokiflavone alleviates high-fat diet-induced erectile dysfunction via the EGFR/PI3K/Akt/eNOS signaling pathway.

ABSTRACT:

Background

Erectile dysfunction (ED) is a significant health issue affecting the global male population, with a complex and multifaceted etiology. High-fat diet (HFD) is known to impair endothelial function and promote the development of ED. Hinokiflavone (HINO), a naturally occurring biflavonoid, has garnered attention for its notable antioxidant and anti-inflammatory activities, suggesting its potential therapeutic role in treating ED.

Aim

This study aims to investigate the therapeutic effects and underlying mechanisms of HINO in HFD-induced ED.

Methods

Network pharmacology and molecular dynamics simulation were employed to predict relevant targets and analyze their binding kinetics. Rat corpus cavernosum endothelial cells (RCCECs) were treated with palmitic acid

SUBMITTER: Gao PC 

PROVIDER: S-EPMC12341904 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature