Molecular profiles in amygdala relevant to the relief of chronic unpredicted mild stress-induced depression by periodic meeting confidantes.

ABSTRACT: Social interaction with confidantes and living in groups are thought of as effective approaches to relieve affective disorders, especially major depression. The molecular mechanisms underlying this effectiveness remain largely unknown. Here, periodic interaction with confidante was used to study the effect of social support on depression-like behaviours induced by chronic unpredicted mild stress (CUMS), and high-throughput sequencing was used to analyse the miRNA and mRNA profiles in amygdala harvested from susceptible mice and resilience mice. The results showed that periodic interaction with confidante ameliorated CUMS-induced depression-like behaviours, and 194 differentially expressed genes (DEGs) were found to be associated with depression-like behaviours, 29 DEGs associated with resi

SUBMITTER: Li Z 

PROVIDER: S-EPMC12341916 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature