Deep brain stimulation surgical timing, outcomes, and prognostic factors in patients with Parkinson's disease: A Chinese retrospective multicenter cohort study.

ABSTRACT:

Background

Deep brain stimulation (DBS) has been increasingly introduced for patients with Parkinson's disease (PD). However, there has been extensive controversy regarding its surgical timing. This study aimed to evaluate surgical outcomes of DBS across different PD durations and identify key prognostic factors.

Methods and findings

In this multicenter cohort study, patients with PD who underwent subthalamic DBS between 1/1/2011 and 12/31/2020 from seven representative Chinese national centers were included. Two-year follow-up data were analyzed, accordingly. These patients were classified into short (<5 years), mid (5-10 years), and long (≥10 years) PD duration groups. Primary assessments included part III of the Movement Disorder Society-sponsored revision of the Unified

SUBMITTER: Wang S 

PROVIDER: S-EPMC12342336 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature