ReAlign-P: a vertical iterative realignment method for protein multiple sequence alignment.

ABSTRACT:

Motivation

Reliable protein multiple sequence alignment (MSA) is essential for downstream biomedical research and directly impacts the accuracy of analytical results. However, protein sequences often exhibit low similarity and complex alignment patterns, and existing general alignment tools frequently fall short in terms of accuracy. Many current realignment methods are outdated, suffering from issues such as code obsolescence and inadequate precision. As a result, there is a pressing need for realignment methods that can better address these challenges.

Results

This study introduces ReAlign-P, a realignment tool designed specifically for protein MSA. ReAlign-P first divides the initial alignment into three regions and applies a novel vertical iterative realignment strategy

SUBMITTER: Zhai Y 

PROVIDER: S-EPMC12342757 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature