Clonal Hematopoiesis of Indeterminate Potential in Crohn's Disease and Ulcerative Colitis.

ABSTRACT:

Background

Clonal hematopoiesis of indeterminate potential (CHIP) is the presence of somatic mutations in myeloid and lymphoid malignancy genes in the blood cells of individuals without a hematologic malignancy. Inflammation is hypothesized to be a key mediator in the progression of CHIP to hematologic malignancy and patients with CHIP have a high prevalence of inflammatory diseases. This study aimed to identify the prevalence and characteristics of CHIP in patients with inflammatory bowel disease (IBD).

Methods

We analyzed whole-exome sequencing data from 587 Crohn's disease (CD), 441 ulcerative colitis (UC), and 293 non-IBD controls to assess CHIP prevalence and used logistic regression to study associations with clinical outcomes.

Results

Older UC patients (age > 4

SUBMITTER: Esai Selvan M 

PROVIDER: S-EPMC12342779 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature