Prevalence, progression, and clinical outcomes of mitral valve prolapse: a systematic review and meta-analysis.

ABSTRACT:

Aims

The prevalence of mitral valve prolapse (MVP) varies across populations and age groups; its natural history and clinical outcomes remain unclear. This meta-analysis established the prevalence of MVP in the general population, in associated syndromes and at different ages. It also determined the rate of progression and the incidence of adverse outcomes.

Methods and results

A systematic search identified original reports on the prevalence of MVP and related outcomes. A total of 83 studies met inclusion: 47 (n = 992 944) non-syndrome associated; 31 (n = 3067) syndrome associated; and 5 (n = 1287) described mitral regurgitation (MR) progression or adverse outcomes. In the general population, the prevalence was 1.35% but higher in hospital cohorts (8.7%). Age-stratified prev

SUBMITTER: Melamed T 

PROVIDER: S-EPMC12342860 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature