Associations between prediagnostic plasma metabolites and biliary tract cancer risk in the prospective UK Biobank cohort.

ABSTRACT: Biliary tract cancer (BTC) is potentially influenced by metabolic dysregulation, yet previous metabolomic evaluations are limited. To address this gap, we prospectively investigated associations of blood metabolites and BTC risk in the UK Biobank cohort study. We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% CIs between 249 plasma metabolites per standard deviation (SD) and BTC risk in 232 781 participants. We implemented exploratory factor analyses and evaluated associations between factors and BTC risk. Associations with a P value <.001 were considered statistically significant after multiple comparison adjustments. In a median follow-up of 11.8 years, we identified 268 first primary incident BTC cases. Of 49 biomarkers significantly associated with BTC ris

SUBMITTER: Gunchick V 

PROVIDER: S-EPMC12342866 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature