Albumin level and risk of major bleeding in patients with atrial fibrillation on direct oral anticoagulants.

ABSTRACT:

Aims

The pharmacological effect of direct oral anticoagulants (DOACs) is influenced by binding status with albumin. This study aimed to assess the association between albumin levels and bleeding risk in atrial fibrillation (AF) patients treated with DOACs.

Methods and results

We conducted DIRECT-Extend registry (N = 7512), a pooled database combining three large-scale observational study of AF patients treated with DOAC. The primary endpoint was major bleeding as defined by International Society on Thrombosis and Haemostasis criteria. Multivariable Cox hazard model was used to assess the impact of albumin level on major bleeding. Out of the overall cohort, 2523 patients [73 (IQR 66-80) years, 1620 (64.2%) males] with albumin data available at enrolment were analyzed in this

SUBMITTER: Sasaki S 

PROVIDER: S-EPMC12343015 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature