Association between sacubitril/valsartan and risk of dementia in patients with heart failure: a nationwide cohort study.

ABSTRACT:

Aims

To evaluate the risk of incident dementia associated with sacubitril/valsartan in patients with heart failure (HF) in South Korea.

Methods and results

We conducted a retrospective cohort study using the National Health Insurance Database in South Korea. Patients diagnosed with HF and prescribed either sacubitril/valsartan or angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptor blockers (ARBs) within 90 days of their first HF diagnosis between October 2017 and December 2020 were included. The primary outcome was incident dementia, categorized into Alzheimer's dementia and vascular dementia. Follow-up began after 1 year from the prescription date, to accommodate dementia onset latency, until the earliest occurrence of dementia, death, or end of study peri

SUBMITTER: Jung K 

PROVIDER: S-EPMC12343040 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature