Cognitive and Patient-Reported Outcome Measures in LGI-1-IgG Autoimmune Encephalitis.

ABSTRACT:

Objective

Clinical outcome measures for autoimmune encephalitis (AE) are not yet well defined. Cognitive outcome measures (CogOs) and patient-reported outcomes (PROs) may capture the symptoms of AE, beyond clinician-reported outcomes (ClinROs) (the Modified Rankin Scale [mRS] and Clinical Assessment Scale in Autoimmune Encephalitis [CASE]).

Methods

This retrospective cohort study examined LGI-1-IgG AE patients at Cleveland Clinic. CogOs included the Rey Auditory Verbal Learning Test (RAVLT) and Brief Visuospatial Memory Test (BVMT). PROs included Neuro-QoL, PROMIS Global Physical (GPH) and Mental Health (GMH). Abnormal RAVLT, BVMT (≤ -1.5 SD), Neuro-QoL, and PROMIS (≥ 10 T-scores) proportions were analyzed. CogOs and PROs were correlated with ClinROs using Spearman's rank co

SUBMITTER: Ongphichetmetha T 

PROVIDER: S-EPMC12343301 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature