CSF Biomarker-Based Cognitive Trajectories in Parkinson's Disease-Subjective Cognitive Decline.

ABSTRACT:

Objective

Cognitive complaints without objective cognitive impairment in Parkinson's Disease, termed Parkinson's Disease-Subjective Cognitive Decline (PD-SCD), have been associated with cognitive decline. However, its progression is heterogeneous, highlighting the need for improved identification of patients at greater risk for deterioration. This cohort study aims to investigate associations between CSF biomarkers and cognitive decline in PD-SCD.

Methods

We included patients from the PPMI cohort with PD-SCD, available baseline CSF beta-amyloid_1-42 (Aβ₄₂) and phosphorylated-tau₁₈₁ (p-tau₁₈₁), and longitudinal Montreal Cognitive Assessment (MoCA).

Results

A total of 80 patients were included, with a mean age of 62.1 years and

SUBMITTER: Rodriguez-Antiguedad J 

PROVIDER: S-EPMC12343326 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature