Investigation of biomarkers and associated molecular mechanism shared between colorectal cancer and lung adenocarcinoma.

ABSTRACT:

Background

The relationship between colorectal cancer (CRC) and lung adenocarcinoma (LUAD) has been acknowledged in recent years, yet the biomarkers and mechanisms underlying their interaction remain unclear. This study aimed to explore the genetic characteristics and molecular mechanisms shared by CRC and LUAD.

Methods

To identify common differentially expressed genes (co-DEGs) between tumor and normal samples, we analyzed gene expression datasets for CRC and LUAD from the GEO and TCGA databases. Then, co-DEGs were further analyzed for enrichment. The survival analysis and protein-protein interaction (PPI) analysis were used to explored biomarkers for two diseases. Based on the identified biomarkers, the functional similarity, immune cell infiltration, and Gene Set Enrichme

SUBMITTER: Gao K 

PROVIDER: S-EPMC12343392 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature