Joint Physical-Psychosocial Frailty and Risks of All-Cause and Cause-Specific Premature Mortality.

ABSTRACT:

Background

The importance of integrating physical and psychosocial factors in assessing frailty -health outcomes has been increasingly acknowledged, while the related evidence is lacking. We sought to investigate the associations of joint physical-psychosocial frailty with risk of premature mortality and evaluate the relative importance of individual physical and psychosocial factors.

Design

A total of 381,295 participants with no history of cancer or cardiovascular disease (CVD) were recruited from the UK Biobank cohort. The physical-psychosocial frailty was evaluated based on seven indicators including weight loss, exhaustion, physical activity, walking pace, grip strength, social isolation, and loneliness. The outcomes were premature mortality from all causes, cancer, CVD

SUBMITTER: Zhou J 

PROVIDER: S-EPMC12343393 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature