Estimated Glomerular Filtration Rate Variability and Incident Heart Failure in Adults With Type 2 Diabetes.

ABSTRACT:

Background

Variability in kidney function, as measured by estimated glomerular filtration rate (eGFR), has been proposed as a novel risk factor for adverse cardiovascular outcomes. However, its association with incident heart failure (HF) in adults with type 2 diabetes remains unclear.

Objectives

The aim of the study was to evaluate the association of eGFR variability with incident HF in a large sample of adults with type 2 diabetes.

Methods

We included participants who had ≥5 eGFR measurements in the first 24 months of the ACCORD (Action to Control Cardiovascular Risk in Diabetes) study. The visit-to-visit variability of eGFR was estimated using the coefficient of variation (CV), SD, and variability independent of the mean. Cox proportional hazards models were used t

SUBMITTER: Kaze AD 

PROVIDER: S-EPMC12343465 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature