Serum proteins and faecal microbiota as potential biomarkers in newly diagnosed, treatment-naive inflammatory bowel disease and irritable bowel syndrome patients.

ABSTRACT: Molecular biomarkers are valuable tools to predict the disease and determine its course. Several markers have been associated with inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS); however, none is sufficiently reliable to enable accurate diagnosis. We characterized a broad panel of serum proteins to assess disease-specific biomarker profiles and associate these findings with faecal microbiota composition in newly diagnosed IBD and IBS patients and healthy individuals. The study cohort consisted of 49 newly diagnosed treatment-naïve adult patients (13 Crohn's disease (CD), 13 ulcerative colitis (UC), and 23 IBS) and 12 healthy individuals. Inflammatory and metabolism-related serum proteins were assessed using PEA multiplex panels, while gut microbiota composition was det

SUBMITTER: Matijasic M 

PROVIDER: S-EPMC12343743 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature