Impact of COVID-19 on growth hormone therapy efficacy in pediatric patients with short stature.

ABSTRACT: The coronavirus disease (COVID-19) pandemic has affected global healthcare and raised concerns about growth hormone (GH) therapy outcomes in pediatric patients with short stature. This study compared GH therapy efficacy and outcomes before and during the pandemic. We retrospectively analyzed 2,827 pediatric patients with idiopathic GH deficiency, short stature in children born small for gestational age (SGA), Turner syndrome (TS), or idiopathic short stature (ISS) from the LG Growth Study, categorized into pre-pandemic (February 2017-January 2020, n = 1,612) and pandemic (February 2020-January 2023, n = 1,215) groups. The key outcomes included height standard deviation score (SDS), body mass index (BMI)-SDS, insulin-like growth factor 1 levels, and adverse events. Significant differences w

SUBMITTER: Kim YM 

PROVIDER: S-EPMC12344362 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature