Factors associated with drug-drug interactions involving citalopram in the UK Biobank.

ABSTRACT:

Background

Adults with mood and/or anxiety disorders have increased risks of comorbidities, chronic treatments and polypharmacy, increasing the risk of drug-drug interactions (DDIs) with antidepressants.

Aims

To use primary care records from the UK Biobank to assess DDIs with citalopram, the most widely prescribed antidepressant in UK primary care.

Method

We classified drugs with pharmacokinetic or pharmacodynamic DDIs with citalopram, then identified prescription windows for these drugs that overlapped with citalopram prescriptions in UK Biobank participants with primary care records. We tested for associations of DDI status (yes/no) with sociodemographic and clinical characteristics and with cytochrome 2C19 activity, using univariate tests, then fitted multivariable

SUBMITTER: Laplace B 

PROVIDER: S-EPMC12344431 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature