A whole-brain voxel-based analysis of structural abnormalities in PTSD: An ENIGMA-PGC study.

ABSTRACT:

Background

Patients with posttraumatic stress disorder (PTSD) exhibit smaller regional brain volumes in commonly reported regions including the amygdala and hippocampus, regions associated with fear and memory processing. In the current study, we have conducted a voxel-based morphometry (VBM) meta-analysis using whole-brain statistical maps with neuroimaging data from the ENIGMA-PGC PTSD working group.

Methods

T1-weighted structural neuroimaging scans from 36 cohorts (PTSD n = 1309; controls n = 2198) were processed using a standardized VBM pipeline (ENIGMA-VBM tool). We meta-analyzed the resulting statistical maps for voxel-wise differences in gray matter (GM) and white matter (WM) volumes between PTSD patients and controls, performed subgroup analyses conside

SUBMITTER: See CRZ 

PROVIDER: S-EPMC12344465 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature