Rocket-Like Microneedle Patch for Sustained Hormone Therapy in Prostate Cancer.

ABSTRACT: Prostate cancer (PCa) remains a significant global health challenge, necessitating the development of advanced therapeutic strategies. This study introduces a rocket-like microneedle patch (RLMNP) as a dual-layer drug delivery system for sustained hormone therapy in PCa. RLMNP integrates a rapid-release layer, employing the pH-responsive zeolitic imidazolate framework-8 (ZIF-8) to encapsulate bicalutamide (CDX), and a sustained-release layer comprising an alginate-tyramine (Alg-Tyr) hydrogel loaded with goserelin. The dual mechanism synergistically targets PCa by blocking androgen receptor signaling and suppressing androgen synthesis. RLMNP demonstrates robust mechanical properties, efficient skin penetration, and controlled drug release profiles. In vivo studies highlight its remar

SUBMITTER: Chen YT 

PROVIDER: S-EPMC12344640 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature