In Situ Bioprinting Enhances Bone Regeneration in a Live Animal Model with Craniofacial Defect.

ABSTRACT: In situ bioprinting represents an innovative approach in tissue engineering and regenerative medicine, enabling direct deposition of bioinks within the body to create or repair tissues at the target site. This technique leverages advanced bioprinting technologies to deliver cells, biomaterials, and bioactive molecules in a precise, controlled manner, offering the potential for on-demand tissue repair and minimizing the need for extensive surgical intervention. In this research, we apply for the first time in the literature a standard 3D bioprinter to perform in situ bioprinting over the bone defects of live animals under anesthesia and discuss the bone regeneration potential. For this, critical-sized bone defects were created on the parietal bones of the rabbits, followed by the applicatio

SUBMITTER: Hindi OA 

PROVIDER: S-EPMC12344647 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature