Photo-Cross-Linked Porous Hybrid Networks Based on Insoluble Collagen and Poly(trimethylene carbonate).

ABSTRACT: Porous hybrid networks were formed from methacrylated collagen (ICol-MA) fibrils and methacrylated PTMC (PTMC-tMA). Dispersing ICol-MA and dissolving PTMC-tMA in DMSO acidified with HCl (DMSO/HCl), followed by mixing, casting, freezing, photo-cross-linking, and solvent extraction, resulted in networks with high porosities and gel contents. ATR-FTIR showed that hybrid networks had compositions similar to the mixture compositions prior to photo-cross-linking. Mechanical testing of porous hybrid networks, in particular the ICol-MA:PTMC-tMA 17:83 wt % network, showed improved mechanical properties compared to non-cross-linked ICol and ICol-MA networks prepared in DMSO/HCl. Additionally, cross-linking alone already improves the properties of porous collagen structures. Interestingly, photo-cros

SUBMITTER: van Bochove B 

PROVIDER: S-EPMC12344706 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature