Body-Wide Expression Profiles of Commonly Assessed Cardiac Biomarkers in a Large Cohort of Human Tissue Donors.

ABSTRACT:

Introduction

Blood biomarkers of myocardial damage or stress are routinely used to guide the diagnosis and management of both acute and chronic cardiac conditions. The circulating levels of these proteins are directly influenced by source tissue expression levels, and understanding where and to what degree they are expressed throughout the body can yield insights into their properties as biomarkers. Thus, in this descriptive study, we sought to comprehensively map the expression of twelve clinically established or emerging cardiac biomarkers across a broad spectrum of human tissues and comparatively assess expression characteristics that could impact diagnostic performance.

Methods

Existing genome-wide mRNA sequencing data originating from 16,357 cardiac and noncardiac tissu

SUBMITTER: O'Connell GC 

PROVIDER: S-EPMC12344743 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature