Ribosome deficiency induces <i>Salmonella</i> filamentation within host cells.

ABSTRACT: The ribosome is the central hub for protein synthesis and is heavily targeted by antibiotics. Ribosomal mutations, antibiotic treatment, and nutrient starvation can alter translational efficiency and lead to stressed cells. Ribosome deficiency plays a critical role in stress responses and disease progression; yet, how it affects bacteria-host interactions remains poorly understood. In this study, we show that a ribosome-deficient strain exhibits a surprising morphological change from rod shape to filamentous in Salmonella cells growing inside host macrophages. Such filamentation depends on an acidic condition within macrophages and in a defined medium mimicking macrophage conditions. Further genetic analyses revealed that filamentation of the ribosome-deficient strain depends on ove

SUBMITTER: Lyu Z 

PROVIDER: S-EPMC12345169 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature