African <i>Salmonella enterica</i> serovar Typhimurium ST313 isolates prevent reactive oxygen species production by human neutrophils via elevated PgtE expression.

ABSTRACT: A recently emerged Salmonella enterica serotype Typhimurium variant, ST313, is a frequent cause of bloodstream infections associated with high mortality rates in sub-Saharan Africa. While the interaction of ST313 strains with macrophages has been studied extensively, interactions with other innate immune effectors such as neutrophils have been largely ignored. We found that a subset of ST313 strains induces an attenuated neutrophil oxidative burst, which can facilitate increased bacterial survival within human neutrophils. The ST313 isolates that avoid triggering potent reactive oxygen species production by neutrophils express elevated levels of the protease PgtE. Increased pgtE expression promotes decreased complement deposition on S. Typhimurium and a concomitant inc

SUBMITTER: Stull-Lane AR 

PROVIDER: S-EPMC12345174 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature