Evidence that hPIV2 paramyxovirus antigenomes are edited during infection.

ABSTRACT: Mononegavirus genomes contain cis-acting sequences that direct the formation of mRNA 5' and 3' ends during synthesis (gene start [GS] and gene end [GE]) but are silent during antigenome synthesis from the same genome template. Paramyxo- and filoviruses also carry an additional cis-acting sequence (EDIT) that directs the insertion of specific nucleotide during mRNA synthesis, expanding gene products. This "mRNA editing" is associated with viruses whose replication is governed by the rule of six. One might, therefore, assume that EDIT, like GS and GE, would be restricted to that of mRNA synthesis. However, accurate determination of the ratio of edited to unedited RNAs in different sub-populations of wild-type and mutant human parainfluenza virus type 2 (hPIV2) infections finds

SUBMITTER: Ohta K 

PROVIDER: S-EPMC12345181 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature