Host-specific adaptation in <i>Fusarium oxysporum</i> correlates with distinct accessory chromosome content in human and plant pathogenic strains.

ABSTRACT: Fusarium oxysporum is a cross-kingdom pathogen. While some strains cause disseminated fusariosis and blinding corneal infections in humans, others are responsible for devastating vascular wilt diseases in plants. To better understand the distinct adaptations of F. oxysporum to animal or plant hosts, we conducted a comparative phenotypic and genetic analysis of two strains: MRL8996 (isolated from a keratitis patient) and Fol4287 (isolated from a wilted tomato [Solanum lycopersicum]). Infection of mouse corneas and tomato plants revealed that, while both strains cause symptoms in both hosts, MRL8996 caused more severe corneal disease in mice, whereas Fol4287 induced more pronounced wilting symptoms in tomato plants. In vitro assays using abiotic stress treatments

SUBMITTER: Ayhan DH 

PROVIDER: S-EPMC12345182 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature