Comparative performance of cobas 4800 HPV Test and Anyplex II HPV HR for high-risk human papillomavirus detection.

ABSTRACT: Numerous molecular tests are available to detect human papillomavirus (HPV). We compared the analytical performance of cobas and Anyplex for detection of high-risk (HR) carcinogenic HPV genotypes, assessed the composition of HPV types (other than 16 and 18) that influenced cobas performance, and considered the impact of viral load on test performance. We used data from the Early Detection of Cervical Cancer in Hard-to-Reach Populations of Women Through Portable and Point-of-Care HPV Testing project, which involved collection (2019-2022) of cervicovaginal samples from 1,042 women aged 21-74 years in Belgium (n = 244), Portugal (n = 309), Brazil (n = 244), and Ecuador (n = 245). Samples were tested by cobas (provides individual results for HPV16 and HPV18 and a po

SUBMITTER: Godoy LR 

PROVIDER: S-EPMC12345211 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature